Joussef Hayek Selected Research

Rett Syndrome (Rett's Disorder)

1/2022	The constitutive activation of TLR4-IRAK1- NFκB axis is involved in the early NLRP3 inflammasome response in peripheral blood mononuclear cells of Rett syndrome patients.
1/2022	Breathing Abnormalities During Sleep and Wakefulness in Rett Syndrome: Clinical Relevance and Paradoxical Relationship With Circulating Pro-oxidant Markers.
6/2021	Altered Bone Status in Rett Syndrome.
4/2021	Circulating 4-F4t-Neuroprostane and 10-F4t-Neuroprostane Are Related to MECP2 Gene Mutation and Natural History in Rett Syndrome.
1/2020	Compromised immune/inflammatory responses in Rett syndrome.
1/2020	Altered inflammasome machinery as a key player in the perpetuation of Rett syndrome oxinflammation.
1/2020	Methyl-CpG-binding protein 2 (MECP2) mutation type is associated with bone disease severity in Rett syndrome.
1/2020	Protective role of mirtazapine in adult female Mecp2+/- mice and patients with Rett syndrome.
1/2020	Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations.
1/2020	Brain protein changes in Mecp2 mouse mutant models: Effects on disease progression of Mecp2 brain specific gene reactivation.

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Joussef Hayek Research Topics

Disease

41	Rett Syndrome (Rett's Disorder) 01/2022 - 08/2009
17	Neurodevelopmental Disorders 06/2021 - 08/2009
6	Disease Progression 04/2021 - 07/2011
6	Autism Spectrum Disorder 01/2017 - 05/2012
5	Inflammation (Inflammations) 01/2022 - 11/2014
5	Autistic Disorder (Autism) 11/2016 - 01/2013
4	Acute-Phase Reaction 03/2017 - 01/2013
3	Intellectual Disability (Idiocy) 01/2020 - 08/2009
3	Brain Diseases (Brain Disorder) 07/2018 - 04/2016
2	Apnea 01/2022 - 01/2014
1	Infections 01/2020
1	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2020
1	Mood Disorders (Mood Disorder) 01/2020
1	Bone Diseases (Bone Disease) 01/2020
1	Globoid Cell Leukodystrophy (Krabbe Disease) 01/2019
1	Nervous System Diseases (Neurological Disorders) 07/2018
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2017
1	Lubs X-linked mental retardation syndrome 01/2016
1	Constipation 01/2016
1	Mitochondrial Diseases (Mitochondrial Disease) 10/2015
1	Multiple Sclerosis 09/2015
1	CDKL5 deficiency disorder 09/2015
1	Chronic Obstructive Pulmonary Disease (COPD) 03/2015
1	Cohen syndrome 10/2010

Drug/Important Bio-Agent (IBA)

27	Methyl-CpG-Binding Protein 2IBA 06/2021 - 08/2009
8	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2013
7	Biomarkers (Surrogate Marker)IBA 04/2021 - 12/2011
5	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 11/2015 - 07/2012
4	LipidsIBA 09/2015 - 12/2011
3	Biological ProductsIBA 04/2021 - 01/2018
3	CytokinesIBA 03/2017 - 01/2015
3	Cyclin-Dependent Kinases (cdk Proteins)IBA 03/2017 - 01/2014
2	IronIBA 01/2022 - 02/2013
2	InflammasomesIBA 01/2022 - 01/2020
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 02/2013
2	ChromatinIBA 06/2021 - 01/2013
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2020 - 10/2015
2	NeuroprostanesIBA 01/2019 - 07/2011
2	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 10/2017 - 02/2013
2	CD5 AntigensIBA 03/2017 - 01/2017
2	Fatty Acids (Saturated Fatty Acids)IBA 11/2015 - 11/2014
2	AntioxidantsIBA 03/2015 - 02/2013
2	high density lipoprotein receptorsIBA 03/2015 - 07/2013
2	Scavenger Receptors (Scavenger Receptor)IBA 03/2015 - 07/2013
2	adrenic acid (7,10,13,16-docosatetraenoic acid)IBA 01/2013 - 12/2011
1	InterleukinsIBA 01/2022
1	Caspase 1 (ICE Protease)IBA 01/2022
1	10-F4t-neuroprostaneIBA 04/2021
1	4-F4t-neuroprostaneIBA 04/2021
1	Mirtazapine (Rexer)FDA LinkGeneric 01/2020
1	Antidepressive Agents (Antidepressants)IBA 01/2020
1	IsoprostanesIBA 01/2019
1	9-hydroxy-10,12-octadecadienoic acidIBA 01/2019
1	13-hydroxy-9,11-octadecadienoic acidIBA 01/2019
1	GalactosylceramidaseIBA 01/2019
1	Complement System Proteins (Complement)IBA 03/2017
1	Interleukin-10 (Interleukin 10)IBA 03/2017
1	Oxygen (Dioxygen)IBA 02/2017
1	Pregnancy-Associated alpha 2-Macroglobulins (alpha 2 Macroglobulin)IBA 01/2017
1	Lipoproteins (Lipoprotein)IBA 01/2017
1	Mannose-Binding Lectin (Mannan-Binding Lectin)IBA 01/2017
1	Apolipoprotein A-I (Apolipoprotein A1)IBA 01/2017
1	Transferrin (beta 2 Transferrin)IBA 01/2017
1	Vitamin D-Binding ProteinIBA 01/2017
1	alpha-Fetoproteins (alpha-Fetoprotein)IBA 01/2017
1	alpha 1-Antitrypsin (alpha 1 Antitrypsin)IBA 01/2017
1	Kininogens (Kininogen)IBA 01/2017
1	Phospholipases A2 (Phospholipase A2)IBA 01/2017
1	AlbuminsIBA 01/2017
1	Blood Proteins (Serum Proteins)IBA 11/2016
1	NucleotidesIBA 04/2016
1	ChemokinesIBA 01/2016
1	Volatile Fatty AcidsIBA 01/2016
1	Peptides (Polypeptides)IBA 09/2015
1	Tocopherols (Tocopherol)IBA 03/2015
1	Carotenoids (Carotene)IBA 03/2015
1	Oxidants (Oxidizing Agents)IBA 03/2015
1	Surface-Active Agents (Surfactants)IBA 03/2015
1	SmokeIBA 03/2015
1	Immunoglobulin M (IgM)IBA 01/2014
1	CholesterolIBA 01/2014
1	Glutathione Disulfide (GSSG)FDA LinkGeneric 01/2014
1	Actins (F Actin)IBA 01/2014
1	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 01/2014
1	Complement C3 (C3 Complement)IBA 01/2013
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2013
1	alpha-1-microglobulinIBA 01/2013
1	HaptoglobinsIBA 01/2013
1	Fibrinogen (Factor I)FDA Link 01/2013
1	Carrier Proteins (Binding Protein)IBA 01/2013
1	ProteomeIBA 01/2013
1	phthalic acid (phthalate)IBA 05/2012
1	CreatineIBA 10/2011
1	X-linked Creatine deficiencyIBA 10/2011
1	Protons (Proton)IBA 10/2011
1	Docosahexaenoic AcidsIBA 07/2011

Therapy/Procedure

1	Duration of Therapy 01/2020
1	Therapeutics 07/2012
1	Ligation 10/2010